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Dr. Hawkins: It was a question that generated more discussion and more divergent views than I would have anticipated. It was a good question in that regard. Knowing the way Western medicine is economically managed these days, if acupuncture is well accepted, you're going to find a lot of pressure to be able to do some kind of home approach eventually. We do an amazing number of things at home now, that were totally unheard of or unthought of just a few years ago. Those are all of my comments. Thank you.

Rankins RC, Hendey GW 1999 ; Effect of a security system on violent incidents and hidden weapons in the emergency department. Annals of Emergency Medicine; 33 6 ; : 676679. Rappard Ph, Parr N 1981 ; Sultorpide et psychoses aigus dysthymiques maniaques. La Semaine Hpitaux; 57 4344 ; : 1841-1843. Raskin VD, Dresner N, Miller LJ 1991 ; Risks of restraints versus psychotropic medication for pregnant patients. American Journal of Psychiatry; 148 12 ; : 1760-1761. Rasmussen K, Levander S 1996 ; Individual rather than situational characteristics predict violence in a maximum security hospital. Journal of Interpersonal Violence; 11 3 ; : 376-390. Rautaharju P, Zhou SH, Wong S, Calhoun HP, Berenson GS, Prineas R, Davignon A 1992 ; Sex differences in the evolution of the electrocardiographic QT interval with age. Canadian Journal of Cardiology; 8: 690-5. Rauter UK, de Nesnera A, Grandfield S 1997 ; Up in smoke? Linking patient assaults to a psychiatric hospital's smoking ban. Journal of Psychosocial Nursing; 35 6 ; : 3540. Ray CL, Subich LM 1998 ; Staff assaults and injuries in a psychiatric hospital as a function of three attitudinal variables. Issues in Mental Health Nursing; 19: 277-289. Ray WA, Meredith S, Thapa PB, Meador KG, Hall K, Murray KT 2001 ; Antipsychotics and the risk of sudden cardiac death. Archives of General Psychiatry; 58: 1161-67. Ray WA, Meador KG 2002 ; Antipsychotics and sudden death: is thioridazine the only bad actor? British Journal of Psychiatry; 180: 483-484. Rees C, Lehane M 1996 ; Witnessing violence to staff: a study of nurses' experience. Nursing Standard; 11 13 15 ; : 45-47. Reid Y, Johnson S, Morant N, Kuipers E, Szmukler G, Bebbington P, Thornicroft G, Prosser D 1999 ; Improving support for mental health staff: a qualitative study. Social Psychiatry and Psychiatric Epidemiology; 34: 309-315. Reinert RE, Hermann CG 1960 ; Unexplained deaths during chlorpromazine therapy. Journal of Nervous and Mental Diseases; 131: 435-42. Reschke RW 1974 ; Parenteral haloperidol for rapid control of severe, disruptive symptoms of acute schizophrenia. Diseases of the Nervous System; 35 3 ; : 112-115. Resnick M, Burton BT 1984 ; Droperidol vs. haloperidol in the initial management of acutely agitated patients. Journal of Clinical Psychiatry; 45 7 ; : 298-299. Reubin T, Spitz, Hillbrand M, Foster HG, Svetina CJ 1997. Reasonably necessary medical treatment is a question of fact to be determined by the Commission. Wright Contracting Co. v. Randall.
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Table 2. Reported Mycobacterium tuberculosis isolates by "reporting" and "originating" province territory, Canada 2007. Ambulatory urodynamics or videourodynamics may also be considered in these circumstances. [D GPP ; ] Research recommendation for urodynamic testing Further research is needed to answer the question of whether the use of urodynamics, prior to initial or subsequent treatments, affects the outcomes and cost effectiveness of interventions in women with UI or OAB and singulair.

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One initiative in acute trusts that can reduce delays is `dispensing for discharge'. This involves prescribing sufficient medicines when first dispensing, in a pack labelled with the patient's details and directions on how to take the medicine, that they can take home with them on discharge. Mental health service users tend to stay in hospital significantly longer than acute trust patients and it is likely that some would need to be dispensed for discharge numerous times before they are finally ready for discharge. Changes to medicines can occur during a stay in hospital, making it wasteful to dispense for discharge too early. Looking at the data by ward type table 10 ; shows very low use of dispensing for discharge. Acute trust ward types all had significantly higher rates, with many showing rates above 60.
Methods Study site and duration The study was conducted in a separate clinic of Mundari Hospital, where MSF has been working since 1997. It is the referral hospital of Kajo Keji County 150 000 inhabitants ; , situated in western Equatoria near the border with 975 and lexapro. Early review of antibiotics essential. Continue therapy until ulcer clean and seen to be healing satisfactorily. May require several weeks of therapy. 67. The parties submit that the third level ATC category N4A, anti-Parkinsons's preparations, generally aim to restore the balance between dopamine and acetylcholine in the brain and have provided information on this bases. Third parties have not contested this market definition. k ; Expectorants R5C ; 68. Expectorants are medicines which promote the secretion of sputum by the air passages, used especially to treat coughs. GW and SB both sell expectorants which fall within the ATC 3 category R5C. 69. Given that the market investigation has not suggested that some other market definition should be used, the assessment will be carried out at the ATC 3 level of R5C. 2. Future markets 70. In the pharmaceuticals industry, a full assessment of the competitive situation requires examination of the products which are not yet on the market but which are at an advanced stage of development, normally after large sums of money have been invested ; . These products are called pipeline products. As noted in the Ciba-Geigy Sandoz decision6, research and development projects undergo three different phases of clinical testing: Phase I marks the start of clinical testing on humans, currently some eight to ten years before a product is marketed. Statistically, projects in phase I generally have no more than a 10% chance of being successful. Phase II, some four to five years before the product is marketed, involves working out the proper dose for the patient and defining the areas of application. The success of phase II is generally acknowledged to be approximately 30%. Phase III, starting three years before the product is marketed, involves establishing the product's effectiveness on larger groups of patients. The risk of failure in phase III is reported to be over 50%. 71. The potential for these products to enter into competition with other products which are either at the development stage or already on the market can be assessed by reference to their characteristics and intended therapeutic use. The Commission has to look at R&D potential in terms of its importance for existing markets, but also for future market situations. 72. In so far as research and development must be assessed in terms of its importance for future markets, the relevant product market can, in the nature of things, be defined in a less clear cut manner than in the case of existing markets. Market definition can be based either on the existing ATC classes or it can be guided primarily by the characteristics of future products as well as by the indications to which they are to be applied. B. Relevant geographic markets 1. Pharmaceutic specialities 73. The Commission has previously defined the geographic markets for pharmaceutical products as being national in scope, despite the trend towards standardisation at a European level. The sale of medicines is influenced by the administrative procedures or and tofranil.

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Drugs Most patients are prescribed 5-aminosalicylic acid 5-ASA ; derivatives, sulphasalazine, mesalazine, olsalazine and balsalazide, which reduce inflammation, to control mild attacks and to maintain remission. Some of these drugs can be given rectally by suppository or enema when disease is confined to the rectum or lower colon. Patients should be encouraged to continue treatment, even when in remission, as 5-ASA drugs reduce the number of relapses and possibly reduce the risk of bowel cancer. However a small number of patients can be intolerant of these drugs causing worsening of their diarrhoea. In more severe attacks, corticosteroids such as hydrocortisone, prednisolone and budesonide Entocorrt ; are needed, and sometimes immunosuppressive agents azathioprine, 6-mercaptopurine, methotrexate, ciclosporin ; are added to treat difficult disease or to reduce the duration of steroid therapy. Some immuosuppressants can take up to four months to be fully effective. In CD, antibiotics and anti-TNF antibodies infliximab ; can provide additional, effective treatment. Corticosteroids can have serious side effects on skin, bones, blood sugar and blood pressure and all immunosuppressants increase the risk of infections. Analgesic, anti-diarrhoeal and anti-spasmodic drugs may be prescribed with caution and supplements of iron, calcium and vitamins D and B12 may be needed. Further information on drugs for IBD is contained in a NACC booklet on the subject. NavalAviation Water Survival Training Instructors NAWS TI ; . Aviation designation is not requured for assignment to NAWSTI duty. Personnel must meet applicable swimming standards outlined elsewhere. Individual NAWSTI personnel may require an aeromedical examination only ifconcurrently applying to or designated for aviation dui and clozaril.
N January 2005, new breast cancer statistics for the United States were released. According to the National Cancer Institute, breast cancer is the most common cancer among women, except for certain skin cancers. This year, about 211, 240 women in the United States will be diagnosed with invasive breast cancer. This is a slightly lower number than projected in 2004, when 215, 990 women were expected to be diagnosed. In addition to invasive breast cancer, 58, 490 new cases of in situ breast cancer will be diagnosed in 2005. A woman's chance of developing breast cancer increases with age. In the United States, a woman has about a one in seven lifetime risk of developing breast cancer. About 40, 410 women will die from the disease this year. Breast cancer is the second leading cause of cancer death in women, after lung cancer. A woman's chance of dying from breast cancer is about 1 in 33 percent. However, it is encouraging that breast cancer death rates continue to decline. This decline is probably the result of earlier detection and improved treatment. Breast cancer also occurs in men. An estimated 1, 690 men will be diagnosed with breast cancer and 460 men will die from it in 2005. There are more than two million breast cancer survivors alive today in the United States.

Grant Programs: Each year the HealthPartners Research Foundation Board of Directors allocates funds to support internal research and partnership grants. Those projects that show scientific merit and the promise of producing meaningful results are considered for funding on a competitive basis. Pilot projects that may evolve into a more developed investigation funded by an external source are encouraged. All employees of HealthPartners are eligible for this program. You can learn more about the programs by going to the website, hprf . The appropriate review subcommittee Health Services, Clinical, and Basic Science ; reviews the applications for scientific merit. The Research Committee makes funding decisions for the HPRF Board of Directors. Grant Cycles and Receipt Dates: HealthPartners Research Foundation internal research grant program has quarterlygrant cycles each year. The receipt dates are quarterly Jan, Apr, Jul, Oct ; on the 3rd Friday of the month. Applications must be received at the Foundation office in the 8170 building by 4: 00 p.m. on the receipt date. Application Forms and Guidelines: The application form, instructions and guidance are available at hprf . Pre-Application Assistance: All research applicants, whether seeking HPRF funding or not, are encouraged to contact Kate Rardin 952-967-5035 ; for clarification of policies and procedures and for referral to experienced investigators and statisticians. This contact should be made as early as possible to insure ample time for assistance. Other Resources: HealthPartners Research Foundation staff is available for consultation on research design, statistical analysis, programming, research subject regulations, and proposal development. IME GME Resident Research Support: Residents in the HealthPartners IME GME residency programs are eligible to receive up to , 000 to support a research project. This funding will be awarded upon receiving approval through the HPRF review process [which includes IRB review]. For more information on this program, contact Connie Jewett and zoloft. Families affected by juvenile arthritis have different strengths and vulnerabilities and can request referral by their GP or rheumatologist to a clinical psychologist or other mental health professional. Having the opportunity to explore thoughts and feelings about JIA and provision of support at difficult transition times can prevent difficulties becoming unmanageable, as you all come to terms with the challenges of living successfully with juvenile arthritis. With thanks to Dr Michele Amos, clinical psychologist, paediatric rheumatology, Great Ormond Street Hospital for Children, London.

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ADVERSE REACTIONS The safety of ENTOCORT EC was evaluated in 651 patients in five short-term, active disease state studies. They ranged in age from 17 to 74 mean 35 ; , 40% were male and 97% were white, 2.6% were 65 years of age. Five hundred and twenty patients were treated with ENTOCORT EC 9 mg total daily dose ; . In general, ENTOCORT EC was well tolerated in these trials. The most common adverse events reported were headache, respiratory infection, nausea, and symptoms of hypercorticism. Clinical studies have shown that the frequency of glucocorticosteroid-associated adverse events was substantially reduced with ENTOCORT EC capsules compared with prednisolone at therapeutically equivalent doses. Adverse events occurring in 5% of the patients are listed in Table 2 and compazine. A. Abnormal Hb structure dominant trait ; 2 mutant Hb Zrich, Hb Seattle ; globin beta chain 63 his : Fe + Methemoglobinemia - + oxidizing drug ; hemolytic anemia b. Diaphorase deficiency or absence recessive trait ; oxidizing drug cyanosis Hb 6-50% MetHb MetHb MetHb --X-- Hb clinical sign. MetHb level 10% : no clinical symptom 510% : cyanosis 20 % : clinically significant symptoms related to tissue hypoxemia ; 2030% : severe symptoms 70% : fatal. Have Medicare A & B Live in 50 states or D.C. Medicare primary Have qualifying condition and need one of covered drugs Not have alternative, comprehensive drug coverage e.g. TriCare, Medicaid, employer sponsored ; May have limited drug coverage e.g. Medi-gap, MediMedicare Advantage and amitriptyline and Entocort online.
Generic Trial Program continued ; The generic trial program offers an alternative to drug companies' heavily marketed brand samples. Medications included in the program are in highly utilized drug classes for treatment of depression, heartburn, high blood pressure, high cholesterol and incontinence. Plan sponsors cover the cost of the trial prescription. This one-time investment results in plan sponsors saving, on average, per prescription for each employee who continues with a generic medication. And employees can save hundreds per year in out-of-pocket costs. Conclusions Subject reports of `diarrhea' associatedwith olestra consumption were not associated with any meaningful or clinically significant increasesin fecal water or electrolyte output. Consumption of sorbitol40g d resulted in rapid-onsetliquid rice-water stools and an increase in mean stool water output of 345.9g d approximately 10 ounces day ; . Consumption of olestra resulted in a dose-responsive, gradual stool softening effect after several days of consumption. The transient increasein incidence of reports of mild to moderate abdominal cramping noted on some of the treatment days in subjectsconsuming 5 ounces of chips 40g d olestra ; for 6 consecutivedays was associated with decreases fecal consistency. These in effects were not severe, poseno risk to health and were not unique to olestra as similar effects were noted in all treatment groups and during baseline and abilify.

References are numbered and listed by their order of appearance in text; the text citation is followed by the appropniate reference number in parentheses. Do not arrange the list. EMLA CREAM EMLA PATCH TRANSDERMAL SYSTEM EMTHEXATE 10 TABLETS 10mg EMTHEXATE PF INJECTION 100mg ml EMTHEXATE PF INJECTION 2.5mg ml EMTHEXATE PF INJECTION 25mg ml, 10ml EMTHEXATE PF INJECTION 25mg ml, 200ml EMTHEXATE PF INJECTION 25mg ml, 2ml EMTHEXATE PF INJECTION 25mg ml, 40ml EMTHEXATE TABLETS 2.5mg ENALAPRIL GOLGI TABLETS 20mg ENALAPRIL GOLGI TABLETS 5mg ENALAPRIL RATIOPHARM TABLETS 20mg ENALAPRIL RATIOPHARM TABLETS 5mg ENATEC-10 TABLETS 10mg ENCEPHABOL LIQUID 16mg ml ENCEPHABOL SUGAR COATED TABLETS 100mg ENDOPRYL TABLETS 5mg ENDOXAN PDR FOR INJ. 1G ENDOXAN PDR FOR INJ. 200mg ENDOXAN PDR FOR INJ. 500mg ENDOXAN SUGAR COATED TABLETS 50mg ENGERIX B PEDIATRIC SUSP. FOR INJ.10MCG PER 0.5ml ENGERIX-B SUSP. FOR INJ.20MCG ml, 1ml ENO FRUIT SALT ORIGINAL, LEMON ; POWDER ENTOCORT CAPSULES 3mg ENTOCORT ENEMA 0.02mg ml EPADOREN SYRUP 75mg 5ml EPALON FILM COATED TABLETS 25mg EPALON FILM COATED TABLETS 50mg EPANUTIN CAPSULES 100mg EPHYNAL CHEWABLE SUGAR COATED TABLETS 100MG. Latory interventions eg, dietary restriction of food allergens or administration of immunoglobulin or antiviral agents ; , detoxification therapies eg, chelation ; , gastrointestinal treatments eg, digestive enzymes, antifungal agents, probiotics, "yeast-free diet, " gluten casein-free diet, and vancomycin ; , and dietary supplement regimens that are purported to act by modulating neurotransmission or through immune factors or epigenetic mechanisms eg, vitamin A, vitamin C, vitamin B6 and magnesium, folic acid, folinic acid, vitamin B12, dimethylglycine and trimethylglycine, carnosine, omega-3 fatty acids, inositol, various minerals, and others ; .203, 204 For most of the aforementioned CAM interventions, there is not enough scientific evidence yet to support or refute their use as treatment for ASDs. However, evaluation of treatments is possible, and a few CAM treatments have been appropriately studied. For example, more than a dozen randomized, double-blind, placebocontrolled trials involving more than 700 patients have demonstrated that secretin a biological treatment ; is not an effective treatment for ASDs.212, 213 Evaluation of nonbiological treatments also is feasible. This has been demonstrated in the case of facilitated communication, a technique that uses a trained facilitator to provide physical support to a nonverbal person's hand or arm while that person uses a computer keyboard or other device to spell. Evidence suggests that the communications produced actually originate from the facilitator214, 215 and that facilitated communication is not a valid treatment for ASDs.216218 Because of methodologic flaws, insufficient numbers of patients, or lack of replication, many CAM therapies have been inadequately evaluated; therefore, evidencebased recommendations for their use are not possible. The most recent and most appropriately designed trials have demonstrated no significant benefit of dimethylglycine, 219, 220 vitamin B6 and magnesium, 221, 222 or auditory integration training.223225 Both positive226 and negative227, 228 results have been described for small, methodologically flawed studies of intravenous immunoglobulin. A recent double-blind, placebo-controlled trial revealed no statistically significant differences on Aberrant Behavior Checklist subscale scores between small groups of children with ASDs who were given omega-3 fatty acids and those who were given placebo.229 However, the investigators noted a trend toward superiority of omega-3 fatty acids over placebo for hyperactivity, which suggests that further investigation may be warranted.229 The gluten casein-free diet is based on a hypothesis of abnormal gut permeability and exogenous opiate excess. Although use of the gluten caseinfree diet for children with ASDs is popular, there is little evidence to support or refute this intervention, and reviewers have determined that meaningful conclusions cannot be drawn from the existing literature.230, 231 Subsequent to these reviews, a randomized, double-blind.

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73% of Calcium Oxalate patients are male. This stone type is unusual in females Breeds at especially high risk include: miniature schnauzers, Lhasa Apso, Yorkshire terriers, miniature poodles, Shih Tzus, and Bichon frises Most cases occur in dogs between ages 5 and 12 years of age!
Bergman H, Wichmann T, deLong MR. Reversal of experimental parkinsonisms by lesions of the subthalamic nucleus. Science. 1990; 249: 1436-1438. Olanow CW, Marsden CD, Lang AE, et al. The role of surgery in Parkinson's disease management. Neurology. 1994; 44: 17S-20S. Pawha R, Wilkinson S, Overman J, et al. Bilateral subthalamic stimulation in patients with Parkinson disease: longterm follow up. J Neurosurg. 2003; 99: 71-77. Lang AE, Duff J, Saint-Cyr JA, et al. Posteroventral medial pallidotomy in Parkinson's disease. J Neurol. 1999; 246 Suppl 2 ; : II28-II41. 5. The deep-brain stimulation for Parkinson's disease study group. Deep-brain stimulation of the subthalamic nucleus or the pars interena of the globus pallidus in Parkinson's disease. N Engl J Med. 2001; 345: 956-963. Limousin P, Krack P, Pollak P, et al. Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease. N Engl J Med. 1998; 339: 1105-1111. Yelnik J, Damier P, Bejjani BP, et al. Functional mapping of the human globus pallidus: contrasting effect of stimulation in the internal and external pallidum in Parkinson's disease. Neuroscience. 2000; 101 1 ; : 77-87. 8. Fahn S, Elton RL, Members of the UPDRS Development Committee. The Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Recent Developments in Parkinson's Disease. Florham Park, NJ: Macmillan Healthcare Information; 1987: 153-163. 9. Benabid AL, Pollak P, Louveau A, et al. Combined Thalamotomy and Stimulation ; Stereotactic Surgery of the VIM Thalamic Nucleus for Bilateral Parkinson Disease. Appl Neurophysiol. 1987; 50: 344-346. Pollak P, Fraix V, Krack P, et al. Treatment results: Parkinson's disease. Mov Disord. 2002; 17 Suppl 3 ; : S75-S83. 11. Saint-Cyr JA, Trepanier L, Kumar R, et al. Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease. Brain. 2000; 123: 2091-2108 and buy zaditor. Inwhitewomenand13.6 3.8 ; inblackwomen, adifference of 55% [95% CI, 51 to 58%]. Vessels from black people tended to be larger, 269 SD 47 ; m white women vs.305 79 ; but our study was not designed to detect differences in vessel diameter. When corrected for vessel diameter, maximalcontractionwas39%[95%CI, 34to45%]higher inblackpeople. Conclusion: These data suggest that specific characteristics of resistance size vessels of black people enhance contractile capacity. The greater contractile capacity in black people could significantly contribute to the greater peripheral resistance and higher blood pressure levels.

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2003 Formulary Changes The AHP Pharmacy and Therapeutics P &T ; Committee makes decisions on which drugs are included or excluded from the drug formulary. The P&T Committee is comprised of physicians, pharmacists and other health care professionals. On a quarterly basis the committee meets to review the current medical and clinical literature, patient utilization, provider recommendations and economic data. This information is reviewed to make decisions about which drugs are safe, effective and produce the desired results. The committee then evaluates the formulary to determine which drugs will be included or excluded from the current drug formulary. In this way, the drug formulary can be adjusted to reflect current medical practice, patient safety, utilization and clinical literature. Here are AHP's formulary changes for 2003. We are currently updating our website under the Broker Employer section to include a PDF file of the 2003 Formulary list. If you would like a copy of the formulary list, please contact the Marketing department. Addition Hepsera Lexapro Xyrem Zelnorm Aranesp Clarines Etocort EC Effective Date 3 1 03.
Evidence marked Joint Exhibit No. 1. DISCUSSION The claimant testified that he is 51 years old and is.
Walmsley, G.L. & Mayer, N.Z. 1973 ; . The Political Economy of Public Organizations. Lexington, MA: Lexington. Walsh, S.L., & Eissenberg, T. 2003 ; . The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic. Drug and Alcohol Dependence 70: S13-S27. Ward, J., Hall, W., & Mattick, R.P. 1999 ; . Role of maintenance treatment in opiate dependence. Lancet 353: 221-6. White, William L. 1998 ; . Slaying the Dragon: The History of Addiction Treatment and Recovery in America. Bloomington, IL: Chestnut Health Systems. Yahr, H.T. 1986 ; . A national comparison of public- and private-sector alcoholism treatment delivery system characteristics. Journal of Studies on Alcohol 49: 233-239. REFERENCES References should be limited to relevant published material cited in text, including all but widely known psychometric tests and scales. Complete literature reviews are rarely necessary. References should be arranged and numbered in order of appearance in text. If a reference is cited more than once, all other citations should be to the original reference number. In text, the reference number appears in parentheses at the end of the material cited rather than after the author's name. ; In the reference list, name all authors through the third; if there are more than three, list the first three and add et al. Citations for journal articles should include author s ; , article title, journal name spelled out, not abbreviated ; , volume number, month or month and day not issue number ; , year, and first and last pages. Example: J. Grant, K. M. Adams, A. S. Carlin, et a!., "Organic Impairment in Polydrug Users: Risk Factors, " Amencanjournal ofPsychiatry, Vol. 135, February 1978, pp. 178- 184. Citations for books should include author s ; or editor s ; , volume or edition designation if there is one, title, publisher, city of publication, year, and, if pertinent, page numbers of the cited material. Example: A. S. Watson, Psychiatry for Lawyers, revised edition, International Universities Press, New York City, 1978. If a chapter in a book is cited, list chapter author s ; , chapter title, book title, volume or edition designation, editor s ; , publisher, city, year, and first and last pages of the chapter. Example: T. P. Detre and D. J. Kupfer, General Hospital Psychiatric Services, " in American Handbook of Psychiatry, Vol. 5, 2nd edition, D. X. Freedman and J. E. Dyrud, editors, Basic Books, New York City, 1975, pp. 607-617. Citations for court cases should follow A Uniform System of Citation, published by the Harvard Law Review Association. Only material that has been published or accepted for publication should be included in a reference list. The source of unpublished material, including personal communications and unpublished papers, should be listed in a footnote keyed with a superscript number ; or noted briefly in text. Manuscripts in press may be included in the reference list; the name of the journal or publisher must be given.
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