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The following drug submissions are currently under review by the Drug Benefit Committee of Pharmacare alendronate FOSAMAX ; , resubmission ancestim STEMGEN ; bisoprolol MONOCOR ; , resubmission bosentan TRACLEER ; botulinium toxin BOTOX ; , new indication donepezil ARICEPT ; entacapone COMTAN ; eprosartan TEVETEN ; , resubmission esomeprazole magnesium trihydrate NEXIUM ; etanercept ENBREL ; filgrastim NEUPOGEN ; , new indication fusidic acid 1% FUCITHALMIC ; galantamine hydrobromide REMINYL ; levonorgestrel releasing intrauterine system MIRENA ; linezolid ZYVOXAM ; mometasone furoate AZMAX Twisthaler ; olanzapine ZYPREXA ; , resubmission oseltamivir TAMIFLU ; , resubmission peginterferon alfa-2b PEG-INTRON ; pioglitazone ACTOS ; , resubmission repaglinide GLUCONORM ; risedronate ACTONEL ; , new indication rivastigmine EXELON ; , resubmission salmon calcitonin nasal spray MIACALCIN ; , resubmission tacrolimus ointment 0.03% & 0.1% ointment PROTOPIC ; testosterone ANDRODERM ; travatan TRAVATAN ; oph soln 0.004.

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A pharmacist reported a near mix-up between Trophamine and tromethamine. Both drugs are packaged in 500 ml glass bottles and stored next to each other in this hospital. T be . vre vns eot i a l Aze r dsae d a l1 eetrp r d n twt l i ' ministered 3 e a REMINYL and at a frequency greater than with placebo combined 1- and 4-week dose-escalation data. Even cause hallucinations or delusions. Many of these medications are seemingly harmless OTC drugs, but of particular concern are some antihistamines, cold preparations and sleep aids pain relievers followed by the letters ; that contain diphenhydramine. It is important to note that in cases of severe allergic reactions, diphenhydramine can save lives, and it is appropriate for seniors as an emergency medication. However, some antihistamines and OTC sleep aids may or may not help someone sleep better, and the hangover effect and other possible negative side effects make these drugs poor choices for older adults with dementia. Much safer alternatives are OTC antihistamines that contain loratidine and the prescription antihistamine fexofenidine. In addition, treating the underlying diseases that interfere with restful sleep, such as pain, depression or anxiety, can make a positive difference. Other environmental interventions, such as changing mattresses, nighttime rituals, room temperature, and dinner foods or portions, and avoiding caffeine, may help someone sleep better than an added medication--without negative side effects. Other anticholinergic medications of concern include muscle relaxants, such as carisoprodol, cyclobenzaprine and methocarbamol, and nausea medications, such as prochlorperazine and promethazine. In addition, note that anticholinergic medications may work against the positive effect of dementia-specific medications. dementia-specific medications. The use of cholinesterase inhibitors--Aricept, Exelon and Razadyne formerly called Reminnyl ; --prescribed for mild to moderate Alzheimer's disease, and Namenda prescribed for moderate to severe Alzheimer's disease have been found to slow the progression of symptoms of Alzheimer's disease. The dose of these medications is typically started slowly and gradually increased to avoid side effects at the onset, such as nausea and diarrhea with cholinesterase inhibitors; discuss this with your treating physician. The Alzheimer's Disease Education & Referral Center, a service of the National Institute on Aging, offers this warning of a drug-drug complication: since both the use of cholinesterase inhibitors and prolonged use of nonsteroidal anti-inflammatory drugs NSAIDs ; such as aspirin or ibuprofen can cause stomach ulcers, NSAIDs should be "used in caution" in combination with cholinesterase inhibitors. medications that act on the brain. A thorough evaluation should be made to determine if using these medications and revia.

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In a further study the ADF then compared the situation in Australian Rules football to cricket, golf and lawn bowls. John Rogerson, Director of the ADF's Good Sports Program, 1658 spoke to this research when he met with the Committee in April 2005, explaining that the research indicated.
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I have the reminyl galamer, in india ; and i only taking 4mg once a day at present. The most common cause of dementia is Alzheimer's disease. As part of the normal progression of the disease, memory loss and personality changes may cause agitation and psychosis. While conventional antipsychotic medications and benzodiazepines can be used to treat these problems, side effects such as tardive dyskinesia, sedation, orthostatic hypotension and falls pose a significant problem in the elderly patient. In an effort to avoid these side effects, other types of medications are now being used to treat dementia-related agitation. Cholinesterase Inhibitors Post-mortem studies of patients with Alzheimer's disease have revealed decreased levels of acetylcholine in the brain. The cholinesterase inhibitors such as Aricept, Exelon and Rem8nyl work by inhibiting the enzymes that break down acetylcholine, thereby increasing the amount of acetylcholine in the brain, which is thought to slow the rate of cognitive decline in Alzheimer's patients. As agitation associated with the progression of dementia significantly correlates with cognitive impairment, slowing a patient's cognitive decline may also slow or prevent the development of agitated behaviors. This has been demonstrated in several clinical trials that have found a correlation between decreased levels of agitation and the initiation of a cholinesterase inhibitor. Anticonvulsants Several studies have reported that carbamazepine Tegretol ; is effective in the treatment of dementia-related agitation. A dose of and parlodel. Age, gender and race: Patient's age, gender, or race did not predict clinical outcome of treatment. INDICATIONS AND USAGE REMINYL galantamine hydrobromide ; is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. CONTRAINDICATIONS REMINYL galantamine hydrobromide ; is contraindicated in patients with known hypersensitivity to galantamine hydrobromide or to any excipients used in the formulation. WARNINGS Anesthesia Galantamine, as a cholinesterase inhibitor, is likely to exaggerate the neuromuscular blockade effects of succinylcholine-type and similar neuromuscular blocking agents during anesthesia. Cardiovascular Conditions Because of their pharmacological action, cholinesterase inhibitors have vagotonic effects on the sinoatrial and atrioventricular nodes, leading to bradycardia and AV block. These actions may be particularly important to patients with supraventricular cardiac conduction disorders or to patients taking other drugs concomitantly that significantly slow heart rate. Postmarketing surveillance of marketed anticholinesterase inhibitors has shown, however, that, bradycardia and all types of heart block have been reported in patients both with and without known underlying cardiac conduction abnormalities. Therefore all patients should be considered at risk for adverse effects on cardiac conduction. In randomized controlled trials, bradycardia was reported more frequently in galantamine-treated patients than in placebo-treated patients, but rarely led to treatment discontinuation. The overall frequency of this event was 2-3% for galantamine doses up to 24 mg day compared with 1% for placebo. No increased incidence of heart block was observed at the recommended doses.

HPI This is the third Cedars Sinai admission of Mrs. Jones a 80 year old African American retired librarian with a history of CAD with MI in 1999, 2-vessel PTCA with stent placement, chronic CHF, past antipsychotic use with resulting tardive dyskinesia, and progressive dementia for the past several years. Her cognitive function and memory have progressively deteriorated to the point where she is unable to carry on a conversation, and her personality has changed over the past several years as well. Her husband, from whom the entire history is obtained, reports that she frequently forgets specific words, occasionally replacing them with unrelated words. Over the past several years she has also fallen numerous times, both at night while attempting to sit on the commode and also during the daytime while walking. None of her falls have been witnessed, but her husband reports that they do not always happen immediately after standing. He also reports that she is not confused after falling, and that he is convinced that she does not lose consciousness; he attributes her falls to instability and weakness. She is able to get around the house relatively well with her walker. For the past several weeks, her general condition has worsened significantly. She has begun falling more frequently, and yesterday fell four times. Her dementia has increased significantly, she has had increasing difficulty dressing herself, and she is considerably more somnolent. She is also drooling more than usual. 4 or 5 days prior to admission she developed a "wet" cough but has not produced much sputum. Over this time she has eaten less, and has lost approximately 5 lbs. She was seen by her PMD Dr. Parker yesterday who noted that she was bradycardic with HR in the 30's and told her to go to the ER. She was admitted to the CCU team, her metoprolol was discontinued, and her HR is now in the 50's. She has transferred to the A medicine team after an acute MI was ruled out. PMH Hypertension Anemia: the patient was hospitalized in late 2000, eventually diagnosed with bleeding gastric ulcers. Rheumatoid arthritis since age 10. This disease has been active for much of her life. Coronary artery disease: MI in 1999, cath revealed EF of 40%, 70% LAD stenosis, 90% LCX stenosis, 80% RCA stenosis. She subsequently underwent PTCA of LCX and OM with stent placement PTCA, 1999 see above ; Hysterectomy, 1999 Penicillin symptoms unknown to husband ; Metoprolol XL 50 mg PO QD Lipitor 10 mg PO QD Hyzaar 100 25 mg PO QD Methotrexate 10 mg Q week Remintl 8 mg PO BID Folate Lidex cream The patient's father had rheumatoid arthritis. Her mother died of a CVA in her 70's There is no other history of heart disease and hydrea.

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Synopsis A study conducted by Pfizer suggests that there is significant regional variation in spending on drugs for Alzheimer's disease in the UK. The study examined the spend in the 52 strategic health authorities and boards across the UK on donepezil Aricept ; , rivastigmine Exelon ; and galantamine Erminyl ; post NICE guidance 2001. The study reported that some areas were spending 8 or more on anti-dementia drugs per head of population over 65, while others were spending less than 2. At the extremes, the Eastern Health and Social Services Board, Northern Ireland, spent 10 per head while Lothian in Scotland spent less than 1. The chief executive of the Alzheimer's Society, said: "People with Alzheimer's disease continue to be denied access to drugs that NICE approved as clinically and cost effective three years ago". The Department of Health has disputed the assumptions of the study and noted that the amount spent on dementia drugs had risen significantly from 4.8 million in 2000 to over 22 million in 2003.

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ADDERALL XR mixed amphetamine salts ; , ADDERALL mixed amphetamine salts ; , AGRYLIN anagrelide hydrochloride ; , AMATINE midodrine hydrochloride ; , CALCICHEW calcium carbonate ; , CARBATROL carbamazepine ; , COLAZIDE balsalazide ; , DEXTROSTAT dextroamphetamine salt ; , EMUTROLTM, ENSOTROL, FARESTONTM toremifene ; FLUVIRAL S F split-virion influenza vaccine ; , FOSRENOL lanthanum carbonate ; , METHYPATCH methylphenidate ; , MICROTROL, MICROTROL DRTM, MICROTROL PRTM, MICROTROL XRTM, OPTISCREEN, PROAMATINE midodrine hydrochloride ; , PROSCREENTM, RAPITROLTM, SOLARAZE diclofenac sodium 3% ; , SOLUTROLTM, TROXATYL troxacitabine ; , XAGRID anagrelide hydrochloride ; . The following are trade marks of third parties: 3TC lamivudine ; trade mark of GlaxoSmithKline GSK , ADEPT 4% icodextrin solution ; trade mark of ml Laboratories plc ; , AZT trade mark of GSK ; , BIO-HEP B trade mark of Berna Biotech AG ; , COMBIVIR trade mark of GSK ; , EPIVIR trade mark of GSK ; , HEPAVAX GENE trade mark of Berna Biotech AG ; , NEISVAC-C trade mark of Baxter International Inc. ; , PENTASA mesalamine ; trade mark of Ferring ; , REMINYL galantamine hydrobromide ; trade mark of Johnson & Johnson ; , TRIZIVIR trade mark of GSK ; , ZEFFIX lamivudine ; trade mark of GSK ; , Concerta trade mark of Johnson & Johnson ; , Metadate CD trade mark of Celltech ; , Ritalin LA trade mark of Novartis ; , Strattera trade mark of Eli Lilly ; , Focalin trade mark of Novartis ; , ASACOL trade mark of Procter & Gamble and nitrofurantoin and Order reminyl. Canada. Janssen-Ortho Inc., under advice from Health Canada, is warning health professionals that according to preliminary data from two investigational studies, galantamine Reminyl ; , a cholinesterase inhibitor, does not appear to be effective in treating patients with mild cognitive impairment MCI ; . In addition, the initial analysis of both studies showed that 15 patients died in the galantamine Reminyl ; treatment group and five in the placebo treated group. The causes of death were mainly cardiovascular or cerebrovascular in nature. Janssen-Ortho is reminding that galantamine Reminyl ; is approved only for the symptomatic treatment of patients with mild to moderate dementia of the Alzheimer's type and that it is not to be used outside of its approved indication.
12-15 EFFICACY AND SAFETY OF GALANTAMINE IN PATIENTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE Galantamine is a new drug that reversibly and competitively inhibits acetylcholinesterase. This randomized, double-blind parallel group, placebo controlled trial evaluated safety and efficacy of galantamine. At 6 months, compared with placebo, the group receiving galantamine had a significantly better outcome on a cognitive scale the decline in cognition slowed ; , better functional ability the decline in functional ability slowed ; , and showed improvement in the judgement of clinicians and caregivers. Activities of daily living were benefited significantly. Compared with placebo, galantamine was effective and well tolerated in treatment of Alzheimer's disease. BMJ December 9, 2000; 321: Original investigation, fist author Gordon K Wilcock, University of Bristol. UK : bmj cgi content full 321 7274 1445 Comment: The FDA has approved galantamine Reminyl ; . I have read it was originally derived from daffodil bulbs and imodium. Parenting. The developmental history of children with SM is usually that they always had a problem with the shyness and fear of talking to strangers, even before they entered school, with parents describing an insidious onset of the mutism, rather than a sudden change in behavior where a child decides to act in a certain way. Behavior that was described in the past as "controlling" may now be seen as trying to avoid very anxiety-provoking and distressing situations, driven by fear rather than by anger. "Children who are mute must have been traumatized." This is what I call the Hollywood version of mutism. It makes for good drama, such as in the rock opera Tommy and the movie The Piano, but it does not correspond to the usual reality of the children I have seen. While cases of mutism have occurred as a result of a child being abused or emotionally or physically traumatized, it seems to be very rare. The typical story in such cases is more like the character in Tommy, who became globally mute, in all settings and with all persons, not selectively mute. I have not yet seen such a case, where a child spoke normally until a traumatic incident and then stopped speaking. Such cases are documented in the medical literature case reports, but in the two systematic studies, including 50 children evaluated by our group at Columbia and 30 evaluated by Drs. Black and Uhde at NIMH, no children were found to have such a history. A report in 1980 by Hayden described "traumatic mutism" as a subgroup of cases reported in a chart review study, but in the paper it is stated that where police or social service reports could be found to document child abuse, the reports always indicated that a child was abused because they were not speaking, not the other way around. Why the author considered this "traumatic mutism" is a mystery. Like so many other psychiatric disorders, it seems that being excessively shy and mute makes a child vulnerable to being taken advantage of or abused. This is a general problem in the mental health field and in our society, confusing cause and effect between bad experiences and mental disorders. Many parents have reported to me that they were suspected of child abuse, some even have been investigated by child welfare agencies, because their child did not talk in school. It is assumed that such children "must be hiding some deep, dark secret" about the family, or an abusive situation, as the reason for mutism. Trauma as an antecedent to SM is clearly the very rare exception, not the rule. "Don't worry, it's just shyness that they will outgrow." Many parents have told me that they hear this often from doctors and educators. While there are undoubtedly many normally shy children who may talk little or none when they first enter a new social situation, it is not normal to remain silent in a classroom indefinitely. We do not have good estimates for the prevalence of SM in this country, as the few epidemiologic studies that have been done on childhood mental disorders in community-based populations have not included SM as a disorder to be studied. A school survey in Britain 30 years ago found a rate of about 7 per 1000 children entering an urban school system, at age 5, were not speaking in the classroom. When surveyed again after a year in school, that number had dropped by a factor of 10, to slightly less than 1 per 1000. The study was confounded by the inclusion of many immigrant children who may not have learned English yet at the time of the first survey, and thus might not have met modern diagnostic criteria for SM. However, the second figure, of about 1 per 1000, is likely to be a truer estimate of the prevalence of SM and matches the finding of a similar survey in Canada done soon after. It would appear that some children do "outgrow it" soon after entering school. This is why the diagnostic criteria now specify that the symptom is not limited to the first few weeks of entering school. However, the consensus now amongst professionals who have seen many children with. Annexure II. The Terms of Reference TOR ; i ; ii ; iii ; iv ; v ; vi ; vii ; viii ; ix ; x ; To identify and prioritize the key areas to be addressed under Agroclimatic Regional Planning. To assess the availability of natural resources and infrastructure necessitated for developing sustainable farming systems and to explore rationalization of region-specific potential for various enterprises. Identify the potential of crops and commodities for different agro-climatic regions and suggest measures to exploit the export commercial potential by way of reducing the production cost. To suggest a viable mechanism for technology development, refinement and adoption as also for operationalizing development programmes on agro-climatic region basis converging existing arrangements. To assess the scope for diversification in agriculture and allied areas so as to harness the ground surface water potential on sub-zone basis keeping in view the comparative advantage. To examine the marketing and value addition related bottlenecks in the development of zonal planning and to suggest measures for correcting them. To assess the performance of the commercial crops in the NE region. To review programmes for the development of Animal Husbandry, Dairying and fishery and to suggest measures for accelerating the growth of these sectors in NE region. To study the trends in capital formation and organic farming in NE region. To review the progress of agricultural development programmes in the North-Eastern States in the 10th Five Year Plan with a view to assessing their impact and suggest improvement.
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Participating providers are contractually obligated to submit claims, either on paper or electronically, to PacifiCare or a delegated payer in time for them to be received within 90 days after the date of service. Obstetrical claims are to be received by PacifiCare within 90 days after delivery. Any corrections to paid or denied claims must be made within 60 days of the original voucher date. Many corrections can be made over the telephone by calling PacifiCare's Provider Customer Service department, a division of the Claims department, at 303-714-5808 if calling from within 303 or 720 area codes or 1-800-8314388 if calling from outside 303 and 720 area codes. When submitting corrections through the mail, do not send a new HCFA form as these are handled as new claims and can be inadvertently denied as untimely. Rather, make photocopy of the voucher page on which the.
Taylor, W.J., Helliwell, P.S. 2004 ; . Diagnostic classification criteria for psoriatic arthritis: methods and process. Current Reports in Rheumatology in press ; . Taylor, W.J., Myers, J., Simpson, R.T., McPherson, K.M., Weatherall, M. 2004 ; . The quality of life of people with rheumatoid arthritis as measured by the WHOQOLBREF instrument: score distributions and psychometric properties. Arthritis Care and Research 51 3 ; : 350-357. Taylor, W.J., Harrison, A.A. 2004 ; . Could the Bath Ankylosing Spondylitis Disease Activity Index BASDAI ; be a valid measure of disease activity in patients with psoriatic arthritis? Arthritis Care and Research 51 3 ; : 311315. Taylor, W.J., Porter, G.G., Helliwell, P.S. 2003 ; . Operational definitions and observer reliability of the plain radiographic features of psoriatic arthritis. Journal of Rheumatology; 30 12 ; : 2645-58. Taylor, W.J. 2002 ; . The epidemiology of psoriatic arthritis. Current Opinion in Rheumatology; 14 2 ; : 98-103 and buy revia. Cash equivalents consisted of interest bearing deposits and repurchase agreements with an initial term of less than three months. December 31, 2004 2003 Trade Receivables, Net Trade receivables. Allowance for doubtful accounts. $ $ 728.7 31.9 ; 696.8 $ $ 658.4 35.6 ; 622.8. Note: because a large number of patients may become refractory to the anticonvulsant effects of the drug over a period of time, the effectiveness of this drug must be re-evaluated after a period of six months. Strong Weed Interestingly, even the cannabis users who have been interviewed in coffee shops in the `strong weed' study many users mostly use their cannabis at home. About one quarter predominantly use cannabis in coffee shops table 42.

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ABUTMENT A tooth or root that retains or supports a fixed bridge or a removable prosthesis. ACCIDENTAL INJURY A condition which is the result of bodily injury caused by an external force; or a condition caused as the result o f an incident which is precipitated by an act of unusual circumstances likely to result in unexpected consequences; this incident must be of a ffi cient departure from the claimant's normal and ordinary lifestyle or routine; the condition must be an instantaneous one, rather than one which continues, progresses or develops. ACTIVELY AT WORK ACTIVE SERVICE ; An Employee is considered to be actively at work when performing, in the customary manner, all of the regular duties of his occupation with the College and is not confined to a hospital or other health care facility. An Employee shall be deemed actively at work on each day o f a regular paid vacation; on a regular non-working day, provided he was actively at work on the last preceding regular working day; or if he is absent solely due to injury or illness. ADOPTED CHILD Any child legally placed in an employee's home by an adoption agency who meets the eligibility requirements of this Plan, whether or not the adoption is final. Placement is defined as the assumption and retention of a leg al obligation for total or partial support of a child in anticipation of adoption of such child. ALLOWABLE EXPENSES Any medically necessary, usual, reasonable, and customary expense, incurred while the Covered Individual is eligible for benefits under this Plan. ALTERNATIVE RECIPIENT Any child of a participant who is recognized under a Qualified Medical Child Support Order QMCSO ; as having a right to enrollment in this Plan with respect to such participant. AMALGAM An alloy of mercury, silver and other metals used as a restorative material in making dies. AMBULATORY OUT-PATIENT SURGICAL CENTER An institution or facility, either free-standing or as part of a hospital, with permanent facilities, equipped and operated for the primary purpose o f performing surgical procedures and to which a patient is admitted to and discharged from within a twenty-four 24 ; hour period. An office maintained by a physician for the practice of medicine or dentistry or for the primary purpose o f perfo rming terminations of pregnancy shall not be considered to be an ambulatory surgical center. AMENDMENT A formal document that changes the provisions of the Plan Document, duly signed by the authorized person or persons as designated by the Plan Administrator. ANNUAL Periodic, based on a Calendar Year. ANTERIOR In the front; the incisors and cuspids. ASSIGNMENT OF BENEFITS Assignment of Benefits occurs when the Covered Person authorizes the Plan to pay benefits directly to the provider of services. BASELINE The initial test results to which the results in future years will be compared in order to detect abnormalities. BENEFITS Those medically necessary services and supplies that qualify for payment under this Plan. 74.

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So when is a pet considered a senior? Generally, smaller breeds of dogs live longer than larger breeds, and cats live longer than dogs. Beyond that, the life span will vary with each individual, and your veterinarian will be able to help you determine what stage of life your furry friend is in. Keep in mind that some small dog breeds may be considered senior at 10-13 years, while giant breeds are classified as seniors at ages as young as five. Your veterinarian is your best source for more information to determine when your pet reaches the golden years.

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Shown that CGRP is not detectable in biological samples without aprotinin. After centrifugation at 1600 g for 15 min, plasma samples were coded and stored at -80C until CGRP measurements were performed. The person measuring CGRP concentrations remained blind to the treatments, until all data had been collated. CGRP was extracted from plasma using a C18 SEP-COLUMN, dried by lypholisation, and measured by radioimmunoassay Dwenger, 1984 ; , as per protocol of the Peninsula Laboratories, Inc. Belmont, CA, U.S.A. ; . The recovery of CGRP from the extraction procedure was ascertained by assaying control samples paired with the same sample spiked with known quantities of CGRP. The column recovery values were 85, 79, 81, and 92% mean 85.2; standard deviation 5.4; coefficient of variation 6.3% ; . The CGRP concentrations measured in the actual samples were, however, not corrected for the loss in the extraction procedure. 4.2.4 Experimental protocol. 02230891 02230892 02227517 C.E.S. C.E.S. Dermatop Diamox Sequels Humulin L Humulin U Iletin II Regular, Pork Iletin II NPH, Pork Intal Spincaps Intropin Methotrexate Protropin Protropin Questran Reminyl Reminyl Reminyl Rhoxal-timolol Rhoxal-timolol Rhodacine Rhodacine Serevent Serevent Tequin Tequin Tilade conjugated estrogen conjugated estrogen prednicarbate acetazolamide insulin zinc human insulin zinc human insulin insulin cromolyn sodium dopamin HCl methotrexate somatrem somatrem cholestyramine resin galantamine hydrobromide galantamine hydrobromide galantamine hydrobromide timolol maleate timolol maleate indomethacin indomethacin salmeterol salmeterol gatifloxacin gatifloxacin nedocromil sodium 0.3 mg 0.9 mg 20 g 500 mg 100 U ml 100 U ml 100 U ml 100 U ml 20 mg 40 mg ml 50 mg 2 ml 5 mg 10 mg 1g 4 mg 8 mg 12 mg 0.25% 0.5% 50 mg 100 mg 25 mcg 50 mcg 200 mg 400 mg 2 mg dose Tablet Tablet Ointment Capsule Injection Injection Injection Injection Powder Injection Injection Injection Injection Tablet Tablet Tablet Tablet Ophthalmic Solution Ophthalmic Solution Suppository Suppository Metered Dose Inhaler Powder for Inhalation Tablet Tablet Inhaler.
Galantamine Reminyl ; Indication vascular dementia Manufacturer Shire Pharmaceuticals Approximate time to market possibly 2003 2004 This acetylcholinesterase inhibitor is currently in Phase III trials for the treatment of vascular dementia. This is the second most common form of dementia, with a worldwide incidence of six to twelve cases per 1, 000 people over 70 years of age. Many other individuals suffer from a mix of Alzheimer's and vascular dementia. Results are available from a randomised double-blind study of 529 patients suffering from either vascular or mixed dementia. After a six week dose-escalation, patients received either galantamine 24mg per day or placebo for six months. Everyone who completed this six month period was then entered into a further six month open label extension phase, in which they all received galantamine 24 mg per day. At the end of the six month double-blind period, the galantamine group demonstrated an improvement in cognition as compared to the placebo group. At twelve months patients who had switched from placebo to galantamine had improvements in cognitive ability compared to baseline. Patients who received the active drug for the whole of the twelve months still had improvements from baseline in cognitive performance, although their mean scores had tailed off from the six month improvement. Further trials are on going. Sources Inpharma 2001; 1299: 13 Risperidone Long-acting injectable Risperdal Consta ; Indication schizophrenia Manufacturer Janssen-Cilag Approximate time to market 2002 This is an intramuscular two-week long-acting injection, which was filed with the Medicines Control Agency for a licence in September 2001. In this new formulation, risperidone is encapsulated into microspheres, which are then dried to form a powder. This is then reconstituted into an aqueous solution for administration. Several new atypical antipsychotic agents are soon to be marketed or are in licensing, including Ziprasidone Pfizer ; . This is a serotonin and dopamine antagonist, which will be available in both oral and parenteral forms. It was to be marketed early 2002, but this may be delayed. Aripiprazole Bristol-Myers Squibb ; has dual agonist antagonist activity at the dopamine D2 ; receptor. A licence application for an oral formulation was submitted to the European licensing agency in December 2001. Iloperidone Novartis ; is another agent under development, but is unlikely to reach the market before 2003 2004. Further information on these products can be found in the NPC UKMI overview "New Developments in Antipsychotic Drug Therapy", May 2001. Sources Scrip July 11th 2001; 2659: Scrip May 9th 11th 2001.

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